Assay Detail
Binding
CHEMBL4392971
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Inhibition of recombinant SIRT2 (unknown origin) using FAM-RHKK(Ac)LM as substrate measured after 60 mins by electrophoretic mobility shift assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New SIRT2 inhibitors: Histidine-based bleomycin spin-off.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.24 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770903 | — | — | 1 | 6.68 |
| CHEMBL4551537 | — | — | 1 | 5.89 |
| CHEMBL4464347 | — | — | 1 | 5.77 |
| CHEMBL4522115 | — | — | 1 | 5.60 |
| CHEMBL4562248 | — | — | 1 | 5.48 |
| CHEMBL4563921 | — | — | 1 | 5.25 |
| CHEMBL4456341 | — | — | 1 | 5.23 |
| CHEMBL4527063 | — | — | 1 | 5.17 |
| CHEMBL4449841 | — | — | 1 | 5.12 |
| CHEMBL4473932 | — | — | 1 | 4.99 |
| CHEMBL4465843 | — | — | 1 | 4.93 |
| CHEMBL4520968 | — | — | 1 | 4.79 |
| CHEMBL4577801 | — | — | 1 | 4.69 |
| CHEMBL4583638 | — | — | 1 | 4.66 |
| CHEMBL4435754 | — | — | 1 | 4.37 |
| CHEMBL4439273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770903 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4551537 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4464347 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4522115 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4562248 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4563921 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4456341 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4527063 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4449841 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4473932 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4465843 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4520968 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4577801 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4583638 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4435754 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4439273 | — | IC50 | > | 100000.0 | nM | - |