Assay Detail
Binding
CHEMBL4393036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured after 60 mins by ADP-Glo luminescence assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.30 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2094331 | — | — | 1 | 8.38 |
| CHEMBL102714 | SB-216763 | — | 1 | 8.08 |
| CHEMBL4474153 | — | — | 1 | 6.81 |
| CHEMBL4450851 | — | — | 1 | 6.63 |
| CHEMBL4514599 | — | — | 1 | 6.46 |
| CHEMBL4440139 | — | — | 1 | 5.91 |
| CHEMBL4529655 | — | — | 1 | 5.76 |
| CHEMBL4454916 | — | — | 1 | 5.36 |
| CHEMBL4436958 | — | — | 1 | 4.89 |
| CHEMBL4465183 | — | — | 1 | 4.70 |
| CHEMBL4101711 | — | — | 1 | - |
| CHEMBL4545169 | — | — | 1 | - |
| CHEMBL4520227 | — | — | 1 | - |
| CHEMBL4585682 | — | — | 1 | - |
| CHEMBL4537467 | — | — | 1 | - |
| CHEMBL4451858 | — | — | 1 | - |
| CHEMBL4517715 | — | — | 1 | - |
| CHEMBL4467292 | — | — | 1 | - |
| CHEMBL4469665 | — | — | 1 | - |
| CHEMBL4578156 | — | — | 1 | - |
| CHEMBL4085946 | — | — | 1 | - |
| CHEMBL4544396 | — | — | 1 | - |
| CHEMBL4464997 | — | — | 1 | - |
| CHEMBL4452454 | — | — | 1 | - |
| CHEMBL4442846 | — | — | 1 | - |
| CHEMBL3360387 | — | — | 1 | - |
| CHEMBL4586793 | — | — | 1 | - |
| CHEMBL4577668 | — | — | 1 | - |
| CHEMBL4549051 | — | — | 1 | - |
| CHEMBL4449604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2094331 | — | IC50 | = | 4.19 | nM | 8.38 |
| CHEMBL102714 | SB-216763 | IC50 | = | 8.35 | nM | 8.08 |
| CHEMBL4474153 | — | IC50 | = | 155.4 | nM | 6.81 |
| CHEMBL4450851 | — | IC50 | = | 232.9 | nM | 6.63 |
| CHEMBL4514599 | — | IC50 | = | 347.9 | nM | 6.46 |
| CHEMBL4440139 | — | IC50 | = | 1231.0 | nM | 5.91 |
| CHEMBL4529655 | — | IC50 | = | 1717.0 | nM | 5.76 |
| CHEMBL4454916 | — | IC50 | = | 4343.0 | nM | 5.36 |
| CHEMBL4436958 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL4465183 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4537467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4451858 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4517715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469665 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4578156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4476606 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2347073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3633203 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4448193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4525020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4516094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4520227 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4545169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4101711 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085946 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4544396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4452454 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442846 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3360387 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4586793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4577668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4549051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4449604 | — | IC50 | > | 10000.0 | nM | - |