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Compound Detail

CHEMBL4585682

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COc1ccc2c(c1)C(O)(CC(=O)c1ccc(C)cc1)C(=O)N2

Basic Information

ChEMBL ID CHEMBL4585682
Phase Preclinical
Structure Type MOL
InChI Key BEHWHZXZNBJWAI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

311.3
MW (Da)
2.42
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H17NO4
MW 311.34
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.15

Activity Summary

IC50 1 meas. best 4.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.22 4.22 60010.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 60010.0 nM 4.22 Inhibition of yeast alpha-glucosidase 34780899

Literature References

PubMed DOI Target Context # Activities
30902399 10.1016/j.bmc.2019.03.028 Glycogen synthase kinase-3 beta 2
34780899 10.1016/j.bmcl.2021.128449 Unchecked 2
30902399 10.1016/j.bmc.2019.03.028 A549 1

Data from ChEMBL 36 via Core Engine