Assay Detail
Binding
CHEMBL5144615
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Inhibition of yeast alpha-glucosidase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel α-glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.39 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4514599 | — | — | 1 | 5.17 |
| CHEMBL5181154 | — | — | 1 | 4.58 |
| CHEMBL5179311 | — | — | 1 | 4.25 |
| CHEMBL4585682 | — | — | 1 | 4.22 |
| CHEMBL5172068 | — | — | 1 | 4.21 |
| CHEMBL5178290 | — | — | 1 | 4.16 |
| CHEMBL5180456 | — | — | 1 | 4.12 |
| CHEMBL5202844 | — | — | 1 | - |
| CHEMBL5198118 | — | — | 1 | - |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4514599 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL5181154 | — | IC50 | = | 26410.0 | nM | 4.58 |
| CHEMBL5179311 | — | IC50 | = | 56560.0 | nM | 4.25 |
| CHEMBL4585682 | — | IC50 | = | 60010.0 | nM | 4.22 |
| CHEMBL5172068 | — | IC50 | = | 62360.0 | nM | 4.21 |
| CHEMBL5178290 | — | IC50 | = | 68910.0 | nM | 4.16 |
| CHEMBL5180456 | — | IC50 | = | 76720.0 | nM | 4.12 |
| CHEMBL5202844 | — | IC50 | = | 153380.0 | nM | - |
| CHEMBL5198118 | — | IC50 | = | 136420.0 | nM | - |
| CHEMBL404271 | ACARBOSE | IC50 | = | 436410.0 | nM | - |