Assay Detail
ADMET
CHEMBL4393039
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Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.90 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.82 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.77 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.48 |
| CHEMBL4545169 | — | — | 1 | 4.73 |
| CHEMBL4469665 | — | — | 1 | 4.65 |
| CHEMBL4578156 | — | — | 1 | 4.50 |
| CHEMBL4474153 | — | — | 1 | 4.35 |
| CHEMBL2094331 | — | — | 1 | 4.32 |
| CHEMBL4520227 | — | — | 1 | 4.17 |
| CHEMBL4448193 | — | — | 1 | 4.09 |
| CHEMBL4476606 | — | — | 1 | 4.04 |
| CHEMBL4537467 | — | — | 1 | - |
| CHEMBL4450851 | — | — | 1 | - |
| CHEMBL4525020 | — | — | 1 | - |
| CHEMBL4514599 | — | — | 1 | - |
| CHEMBL3633203 | — | — | 1 | - |
| CHEMBL2347073 | — | — | 1 | - |
| CHEMBL4517715 | — | — | 1 | - |
| CHEMBL4465183 | — | — | 1 | - |
| CHEMBL4451858 | — | — | 1 | - |
| CHEMBL4452454 | — | — | 1 | - |
| CHEMBL4436958 | — | — | 1 | - |
| CHEMBL4585682 | — | — | 1 | - |
| CHEMBL4440139 | — | — | 1 | - |
| CHEMBL3360387 | — | — | 1 | - |
| CHEMBL4586793 | — | — | 1 | - |
| CHEMBL4549051 | — | — | 1 | - |
| CHEMBL4577668 | — | — | 1 | - |
| CHEMBL4467292 | — | — | 1 | - |
| CHEMBL4529655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4545169 | — | IC50 | = | 18710.0 | nM | 4.73 |
| CHEMBL4469665 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL4578156 | — | IC50 | = | 31430.0 | nM | 4.50 |
| CHEMBL4474153 | — | IC50 | = | 44430.0 | nM | 4.35 |
| CHEMBL2094331 | — | IC50 | = | 47970.0 | nM | 4.32 |
| CHEMBL4520227 | — | IC50 | = | 67450.0 | nM | 4.17 |
| CHEMBL4448193 | — | IC50 | = | 80270.0 | nM | 4.09 |
| CHEMBL4476606 | — | IC50 | = | 90560.0 | nM | 4.04 |
| CHEMBL4517715 | — | IC50 | = | 449070.0 | nM | - |
| CHEMBL2347073 | — | IC50 | = | 594740.0 | nM | - |
| CHEMBL3633203 | — | IC50 | = | 491010.0 | nM | - |
| CHEMBL4514599 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4525020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4450851 | — | IC50 | = | 148990.0 | nM | - |
| CHEMBL4537467 | — | IC50 | = | 175830.0 | nM | - |
| CHEMBL4438406 | — | IC50 | = | 146250.0 | nM | - |
| CHEMBL4516094 | — | IC50 | = | 200900.0 | nM | - |
| CHEMBL4454916 | — | IC50 | = | 412170.0 | nM | - |
| CHEMBL4580857 | — | IC50 | = | 241710.0 | nM | - |
| CHEMBL4465183 | — | IC50 | - | — | - | |
| CHEMBL4451858 | — | IC50 | = | 428590.0 | nM | - |
| CHEMBL4452454 | — | IC50 | - | — | - | |
| CHEMBL4436958 | — | IC50 | = | 328550.0 | nM | - |
| CHEMBL4585682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4440139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3360387 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4586793 | — | IC50 | = | 170630.0 | nM | - |
| CHEMBL4549051 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4577668 | — | IC50 | = | 473550.0 | nM | - |
| CHEMBL4467292 | — | IC50 | = | 426530.0 | nM | - |
| CHEMBL4529655 | — | IC50 | > | 100000.0 | nM | - |