Assay Detail
ADMET
CHEMBL4393356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition and measured by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.25 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267178 | — | — | 1 | 7.96 |
| CHEMBL4584968 | — | — | 1 | 6.97 |
| CHEMBL4527411 | — | — | 1 | 6.92 |
| CHEMBL4452902 | — | — | 1 | 6.14 |
| CHEMBL4437091 | — | — | 1 | 6.07 |
| CHEMBL4441587 | — | — | 1 | 6.00 |
| CHEMBL4536692 | — | — | 1 | 5.75 |
| CHEMBL4592738 | — | — | 1 | 5.40 |
| CHEMBL4556395 | — | — | 1 | 5.05 |
| CHEMBL4463640 | — | — | 1 | - |
| CHEMBL4449693 | — | — | 1 | - |
| CHEMBL4539203 | — | — | 1 | - |
| CHEMBL4465363 | — | — | 1 | - |
| CHEMBL4465665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267178 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4584968 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4527411 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4452902 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL4437091 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL4441587 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4536692 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4592738 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4556395 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4463640 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4449693 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4539203 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4465363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4465665 | — | IC50 | > | 10000.0 | nM | - |