Assay Detail
Binding
CHEMBL4393365
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Inhibition of AChE in erythrocytes (unknown origin) pre-incubated for 20 mins before acetylthiocholine substrate addition and measured over 30 mins by DTNB dye based spectrophotometry
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski's filter to develop novel anti-neurodegenerative drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 8 | - | - |
| IC50 | 1 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519496 | — | — | 2 | 6.60 |
| CHEMBL1200569 | CAFFEINE CITRATE | 4.0 | 1 | - |
| CHEMBL4554996 | — | — | 1 | - |
| CHEMBL4576139 | — | — | 1 | - |
| CHEMBL4437448 | — | — | 1 | - |
| CHEMBL4527412 | — | — | 1 | - |
| CHEMBL4452323 | — | — | 1 | - |
| CHEMBL4452426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519496 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1200569 | CAFFEINE CITRATE | Inhibition | - | % | - | |
| CHEMBL4554996 | — | Inhibition | - | % | - | |
| CHEMBL4576139 | — | Inhibition | - | % | - | |
| CHEMBL4437448 | — | Inhibition | - | % | - | |
| CHEMBL4519496 | — | Inhibition | - | % | - | |
| CHEMBL4527412 | — | Inhibition | - | % | - | |
| CHEMBL4452323 | — | Inhibition | - | % | - | |
| CHEMBL4452426 | — | Inhibition | - | % | - |