Assay Detail
Binding
CHEMBL4393397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human ERbeta assessed as induction of transcriptional activation incubated for 24 hrs by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of hydrogen peroxide activated estrogen receptor beta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.52 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.70 |
| CHEMBL4456753 | — | — | 1 | 6.33 |
| CHEMBL334773 | DIARYLPROPIONITRILE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4456753 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL334773 | DIARYLPROPIONITRILE | EC50 | = | 720000.0 | nM | - |