Assay Detail
Functional
CHEMBL4393480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW 1116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.36 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436031 | — | — | 1 | 8.82 |
| CHEMBL4451053 | — | — | 1 | 8.82 |
| CHEMBL136985 | VERRUCARIN A | — | 1 | 8.74 |
| CHEMBL4435499 | — | — | 1 | 8.51 |
| CHEMBL1080066 | 16-HYDROXY VERRUCARIN A | — | 1 | 7.92 |
| CHEMBL4459598 | — | — | 1 | 7.48 |
| CHEMBL509175 | RORIDIN E | — | 1 | 7.41 |
| CHEMBL4555484 | — | — | 1 | 6.80 |
| CHEMBL4515580 | — | — | 1 | 6.75 |
| CHEMBL4544523 | — | — | 1 | 6.70 |
| CHEMBL334648 | RORIDIN A | — | 1 | 6.68 |
| CHEMBL4449215 | — | — | 1 | 6.26 |
| CHEMBL4566134 | — | — | 1 | 6.24 |
| CHEMBL4551089 | — | — | 1 | 5.64 |
| CHEMBL4463340 | — | — | 1 | 5.37 |
| CHEMBL4567360 | — | — | 1 | 5.10 |
| CHEMBL447144 | — | — | 1 | 5.04 |
| CHEMBL4459838 | — | — | 1 | 4.97 |
| CHEMBL4513960 | — | — | 1 | 4.93 |
| CHEMBL4465899 | — | — | 1 | 4.68 |
| CHEMBL4544860 | — | — | 1 | 4.64 |
| CHEMBL4444618 | — | — | 1 | 4.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436031 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4451053 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL136985 | VERRUCARIN A | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4435499 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1080066 | 16-HYDROXY VERRUCARIN A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4459598 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL509175 | RORIDIN E | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4555484 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4515580 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4544523 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL334648 | RORIDIN A | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4449215 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4566134 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4551089 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4463340 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4567360 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL447144 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL4459838 | — | IC50 | = | 10620.0 | nM | 4.97 |
| CHEMBL4513960 | — | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL4465899 | — | IC50 | = | 21070.0 | nM | 4.68 |
| CHEMBL4544860 | — | IC50 | = | 23130.0 | nM | 4.64 |
| CHEMBL4444618 | — | IC50 | = | 22710.0 | nM | 4.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 76920.0 | nM | 4.11 |