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Assay Detail

CHEMBL4393627

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T-cell
Confidence 1 — Organism
Curated By Autocuration

Target

T-cell (CHEMBL614309)
Type CELL-LINE

Publication

Sesquiterpene Lactones from Artemisia argyi: Absolute Configuration and Immunosuppressant Activity.
Reinhardt JK, Klemd AM, Danton O, De Mieri M, Smieško M, Huber R, Bürgi T, Gründemann C, Hamburger M.
J Nat Prod (2019) 82 : 1424 -1433
PubMed 31181920 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.51 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160 CYCLOSPORINE 4.0 1 6.70
CHEMBL513501 SECOTANAPARTHOLIDE B 1 6.00
CHEMBL467620 1 5.92
CHEMBL4518431 1 5.72
CHEMBL271164 ARTECANIN 1 5.57
CHEMBL4452921 1 5.50
CHEMBL467832 1 5.43
CHEMBL487601 JACEOSIDINE 1 5.24
CHEMBL312750 EUPATILIN -1.0 1 4.93
CHEMBL4514117 1 4.86
CHEMBL89311 SANTAMARIN 1 4.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160 CYCLOSPORINE IC50 = 200.0 nM 6.70
CHEMBL513501 SECOTANAPARTHOLIDE B IC50 = 1000.0 nM 6.00
CHEMBL467620 IC50 = 1200.0 nM 5.92
CHEMBL4518431 IC50 = 1900.0 nM 5.72
CHEMBL271164 ARTECANIN IC50 = 2700.0 nM 5.57
CHEMBL4452921 IC50 = 3200.0 nM 5.50
CHEMBL467832 IC50 = 3700.0 nM 5.43
CHEMBL487601 JACEOSIDINE IC50 = 5800.0 nM 5.24
CHEMBL312750 EUPATILIN IC50 = 11700.0 nM 4.93
CHEMBL4514117 IC50 = 13800.0 nM 4.86
CHEMBL89311 SANTAMARIN IC50 = 19600.0 nM 4.71