Assay Detail
Binding
CHEMBL4393769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.70 | 9.30 |
| Ki | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 9.30 |
| CHEMBL4576860 | — | — | 1 | 6.50 |
| CHEMBL4434674 | — | — | 1 | 6.30 |
| CHEMBL4469359 | — | — | 1 | 5.90 |
| CHEMBL4527331 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4576860 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4434674 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4469359 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4527331 | — | IC50 | = | 8380.0 | nM | 5.08 |