Assay Detail
Binding
CHEMBL4393774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.22 | 8.43 |
| Ki | 1 | 6.20 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 8.43 |
| CHEMBL4434674 | — | — | 1 | 6.20 |
| CHEMBL4576860 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218576 | COPANLISIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4434674 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL4576860 | — | IC50 | = | 1000.0 | nM | 6.00 |