Assay Detail
Binding
CHEMBL4394423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PD1/PDL1 protein-protein interaction after 15 mins by HTRF assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.12 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582252 | — | — | 1 | 7.10 |
| CHEMBL4586685 | — | — | 1 | 7.04 |
| CHEMBL4452790 | — | — | 1 | 6.62 |
| CHEMBL4520349 | — | — | 1 | 6.56 |
| CHEMBL4442851 | — | — | 1 | 6.43 |
| CHEMBL4455608 | — | — | 1 | 6.43 |
| CHEMBL4543102 | — | — | 1 | 6.32 |
| CHEMBL4457544 | — | — | 1 | 6.31 |
| CHEMBL4475015 | — | — | 1 | 6.25 |
| CHEMBL4541583 | — | — | 1 | 6.13 |
| CHEMBL4519100 | — | — | 1 | 6.12 |
| CHEMBL4439532 | — | — | 1 | 6.08 |
| CHEMBL4447172 | — | — | 1 | 6.01 |
| CHEMBL4568718 | — | — | 1 | 6.01 |
| CHEMBL4563134 | — | — | 1 | 6.00 |
| CHEMBL4592820 | — | — | 1 | 5.87 |
| CHEMBL4546533 | — | — | 1 | 5.83 |
| CHEMBL4450074 | — | — | 1 | 5.53 |
| CHEMBL4471246 | — | — | 1 | 5.43 |
| CHEMBL4466921 | — | — | 1 | 5.29 |
| CHEMBL4520858 | — | — | 1 | 5.25 |
| CHEMBL4452395 | — | — | 1 | - |
| CHEMBL4562589 | — | — | 1 | - |
| CHEMBL4457101 | — | — | 1 | - |
| CHEMBL4466516 | — | — | 1 | - |
| CHEMBL4458370 | — | — | 1 | - |
| CHEMBL4567561 | — | — | 1 | - |
| CHEMBL4435975 | — | — | 1 | - |
| CHEMBL4585208 | — | — | 1 | - |
| CHEMBL4568379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582252 | — | IC50 | = | 79.5 | nM | 7.10 |
| CHEMBL4586685 | — | IC50 | = | 92.3 | nM | 7.04 |
| CHEMBL4452790 | — | IC50 | = | 238.3 | nM | 6.62 |
| CHEMBL4520349 | — | IC50 | = | 274.6 | nM | 6.56 |
| CHEMBL4442851 | — | IC50 | = | 374.6 | nM | 6.43 |
| CHEMBL4455608 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL4543102 | — | IC50 | = | 473.8 | nM | 6.32 |
| CHEMBL4457544 | — | IC50 | = | 486.2 | nM | 6.31 |
| CHEMBL4475015 | — | IC50 | = | 565.8 | nM | 6.25 |
| CHEMBL4541583 | — | IC50 | = | 733.3 | nM | 6.13 |
| CHEMBL4519100 | — | IC50 | = | 754.7 | nM | 6.12 |
| CHEMBL4439532 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL4447172 | — | IC50 | = | 983.4 | nM | 6.01 |
| CHEMBL4568718 | — | IC50 | = | 968.1 | nM | 6.01 |
| CHEMBL4563134 | — | IC50 | = | 987.8 | nM | 6.00 |
| CHEMBL4592820 | — | IC50 | = | 1347.0 | nM | 5.87 |
| CHEMBL4546533 | — | IC50 | = | 1487.0 | nM | 5.83 |
| CHEMBL4450074 | — | IC50 | = | 2945.0 | nM | 5.53 |
| CHEMBL4471246 | — | IC50 | = | 3694.0 | nM | 5.43 |
| CHEMBL4466921 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL4520858 | — | IC50 | = | 5566.0 | nM | 5.25 |
| CHEMBL4452395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4562589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4457101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4466516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4458370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4567561 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435975 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4568379 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530283 | — | IC50 | > | 10000.0 | nM | - |