Assay Detail
ADMET
CHEMBL4394965
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Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087968 | — | — | 1 | 5.62 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.62 |
| CHEMBL4474354 | — | — | 1 | 5.60 |
| CHEMBL4538745 | — | — | 1 | 5.47 |
| CHEMBL4589605 | — | — | 1 | 5.40 |
| CHEMBL4573943 | — | — | 1 | 5.32 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087968 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4474354 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4538745 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4589605 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4573943 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 9050.0 | nM | 5.04 |