Assay Detail
Functional
CHEMBL4395364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 90-13 reduction in parasite growth after 72 hrs by resazurin dye based fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.81 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.85 |
| CHEMBL4567421 | — | — | 1 | 7.52 |
| CHEMBL4539329 | — | — | 1 | 7.22 |
| CHEMBL4528408 | — | — | 1 | 6.77 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.62 |
| CHEMBL4513343 | — | — | 1 | 5.16 |
| CHEMBL4450235 | — | — | 1 | 5.11 |
| CHEMBL4443875 | — | — | 1 | 5.11 |
| CHEMBL4539930 | — | — | 1 | 5.04 |
| CHEMBL4526853 | — | — | 1 | 4.97 |
| CHEMBL4472833 | — | — | 1 | 4.88 |
| CHEMBL4559714 | — | — | 1 | 4.85 |
| CHEMBL4462037 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4567421 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4539329 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4528408 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4513343 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL4450235 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL4443875 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL4539930 | — | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL4526853 | — | IC50 | = | 10630.0 | nM | 4.97 |
| CHEMBL4472833 | — | IC50 | = | 13130.0 | nM | 4.88 |
| CHEMBL4559714 | — | IC50 | = | 14040.0 | nM | 4.85 |
| CHEMBL4462037 | — | IC50 | = | 34840.0 | nM | 4.46 |