Assay Detail
Binding
CHEMBL4395839
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Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISA
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.50 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452170 | — | — | 1 | 8.52 |
| CHEMBL4513323 | — | — | 1 | 7.89 |
| CHEMBL4446519 | — | — | 1 | 7.85 |
| CHEMBL4442468 | — | — | 1 | 7.82 |
| CHEMBL4434855 | — | — | 1 | 7.82 |
| CHEMBL4536012 | — | — | 1 | 7.80 |
| CHEMBL4476843 | — | — | 1 | 7.75 |
| CHEMBL4446355 | — | — | 1 | 7.75 |
| CHEMBL4476724 | — | — | 1 | 7.75 |
| CHEMBL4457096 | — | — | 1 | 7.72 |
| CHEMBL4455711 | — | — | 1 | 7.72 |
| CHEMBL4437018 | — | — | 1 | 7.70 |
| CHEMBL4458096 | — | — | 1 | 7.70 |
| CHEMBL4473730 | — | — | 1 | 7.70 |
| CHEMBL4571942 | — | — | 1 | 7.68 |
| CHEMBL4555253 | — | — | 1 | 7.66 |
| CHEMBL4566059 | — | — | 1 | 7.64 |
| CHEMBL4474903 | — | — | 1 | 7.62 |
| CHEMBL4561291 | — | — | 1 | 7.57 |
| CHEMBL4518955 | — | — | 1 | 7.57 |
| CHEMBL4568095 | — | — | 1 | 7.57 |
| CHEMBL4441042 | — | — | 1 | 7.55 |
| CHEMBL4555766 | — | — | 1 | 7.54 |
| CHEMBL4449570 | — | — | 1 | 7.54 |
| CHEMBL4592870 | — | — | 1 | 7.44 |
| CHEMBL4435922 | — | — | 1 | 7.42 |
| CHEMBL4574237 | — | — | 1 | 7.40 |
| CHEMBL10 | SB-203580 | — | 1 | 7.39 |
| CHEMBL4546015 | — | — | 1 | 7.39 |
| CHEMBL4475119 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452170 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4513323 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4446519 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4442468 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4434855 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4536012 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4476843 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4446355 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4476724 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4457096 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4455711 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4437018 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4473730 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4458096 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4571942 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4555253 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4566059 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4474903 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4568095 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4518955 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4561291 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4441042 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4555766 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4449570 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4592870 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4435922 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4574237 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL10 | SB-203580 | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4546015 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4475119 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4589431 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1773425 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4591390 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4547931 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4452736 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4520113 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4454724 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL1272270 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL4449296 | — | IC50 | = | 1603.0 | nM | 5.79 |