Assay Detail
Binding
CHEMBL4396177
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Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.33 | 6.85 |
| IC50 | 2 | 6.05 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579120 | — | — | 2 | 6.85 |
| CHEMBL4562303 | — | — | 2 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579120 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4579120 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4562303 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4562303 | — | IC50 | = | 3000.0 | nM | 5.52 |