Assay Detail
Binding
CHEMBL4396426
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Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit epsilon (CHEMBL4961) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of the "hidden" multifunctional agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.72 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571835 | — | — | 1 | 5.92 |
| CHEMBL4594074 | — | — | 1 | 5.08 |
| CHEMBL4459614 | — | — | 1 | 5.06 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.05 |
| CHEMBL4470950 | — | — | 1 | 4.87 |
| CHEMBL4468053 | — | — | 1 | 4.79 |
| CHEMBL4452617 | — | — | 1 | 4.74 |
| CHEMBL4452986 | — | — | 1 | 4.69 |
| CHEMBL4566337 | — | — | 1 | 4.54 |
| CHEMBL4443818 | — | — | 1 | 4.54 |
| CHEMBL4471688 | — | — | 1 | 4.39 |
| CHEMBL4517494 | — | — | 1 | 4.38 |
| CHEMBL4535921 | — | — | 1 | 4.31 |
| CHEMBL4446271 | — | — | 1 | 4.26 |
| CHEMBL4557064 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571835 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4594074 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4459614 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4470950 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4468053 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4452617 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4452986 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL4566337 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL4443818 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4471688 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL4517494 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL4535921 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL4446271 | — | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL4557064 | — | IC50 | = | 69900.0 | nM | 4.16 |