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Assay Detail

CHEMBL4396797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against FIV infected in cat FL-4 cells assessed as reduction in viral RNA level measured after 7 days by qRT-PCR analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Feline immunodeficiency virus
Confidence 1 — Organism
Curated By Autocuration

Target

Feline immunodeficiency virus (CHEMBL613744)
Type ORGANISM
Organism Feline immunodeficiency virus

Publication

Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection.
Asquith CRM, Sil BC, Laitinen T, Tizzard GJ, Coles SJ, Poso A, Hofmann-Lehmann R, Hilton ST.
Bioorg Med Chem (2019) 27 : 4174 -4184
PubMed 31395510 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 6.43 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1089316 CHAETOCIN 1 8.77
CHEMBL254316 RALTEGRAVIR 4.0 1 8.00
CHEMBL4450206 1 7.47
CHEMBL4530384 1 7.28
CHEMBL4452186 1 7.06
CHEMBL4548884 1 6.96
CHEMBL4475816 1 6.80
CHEMBL4550800 1 6.39
CHEMBL4463943 1 6.26
CHEMBL4452306 1 6.20
CHEMBL4560837 1 6.06
CHEMBL4574988 1 6.05
CHEMBL4453166 1 6.04
CHEMBL4445634 1 5.80
CHEMBL4576093 1 5.75
CHEMBL4524919 1 5.72
CHEMBL4434690 1 5.68
CHEMBL4450224 1 5.52
CHEMBL3124975 1 5.41
CHEMBL129 ZIDOVUDINE 4.0 1 5.28
CHEMBL4530926 1 -
CHEMBL4532328 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1089316 CHAETOCIN EC50 = 1.7 nM 8.77
CHEMBL254316 RALTEGRAVIR EC50 = 10.0 nM 8.00
CHEMBL4450206 EC50 = 34.0 nM 7.47
CHEMBL4530384 EC50 = 53.0 nM 7.28
CHEMBL4452186 EC50 = 88.0 nM 7.06
CHEMBL4548884 EC50 = 110.0 nM 6.96
CHEMBL4475816 EC50 = 160.0 nM 6.80
CHEMBL4550800 EC50 = 410.0 nM 6.39
CHEMBL4463943 EC50 = 550.0 nM 6.26
CHEMBL4452306 EC50 = 630.0 nM 6.20
CHEMBL4560837 EC50 = 880.0 nM 6.06
CHEMBL4574988 EC50 = 890.0 nM 6.05
CHEMBL4453166 EC50 = 910.0 nM 6.04
CHEMBL4445634 EC50 = 1600.0 nM 5.80
CHEMBL4576093 EC50 = 1800.0 nM 5.75
CHEMBL4524919 EC50 = 1900.0 nM 5.72
CHEMBL4434690 EC50 = 2100.0 nM 5.68
CHEMBL4450224 EC50 = 3000.0 nM 5.52
CHEMBL3124975 EC50 = 3900.0 nM 5.41
CHEMBL129 ZIDOVUDINE EC50 = 5300.0 nM 5.28
CHEMBL4530926 EC50 > 10000.0 nM -
CHEMBL4532328 EC50 > 100000.0 nM -