Assay Detail
Functional
CHEMBL4397058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HUVEC measured after 3 days by CyQUANT reagent-based fluorescence assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.79 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475680 | — | — | 1 | 7.82 |
| CHEMBL4466601 | — | — | 1 | 7.50 |
| CHEMBL4552396 | — | — | 1 | 7.00 |
| CHEMBL4524329 | — | — | 1 | 6.77 |
| CHEMBL4465025 | — | — | 1 | 6.62 |
| CHEMBL4558399 | — | — | 1 | 6.60 |
| CHEMBL4464652 | — | — | 1 | 6.55 |
| CHEMBL4546986 | — | — | 1 | 6.52 |
| CHEMBL4460784 | — | — | 1 | 6.51 |
| CHEMBL4462995 | — | — | 1 | 6.46 |
| CHEMBL4549484 | — | — | 1 | 5.82 |
| CHEMBL4536649 | — | — | 1 | 5.80 |
| CHEMBL4584721 | — | — | 1 | 5.80 |
| CHEMBL4469817 | — | — | 1 | 5.77 |
| CHEMBL4566670 | — | — | 1 | 5.72 |
| CHEMBL4441859 | — | — | 1 | 5.60 |
| CHEMBL4463329 | — | — | 1 | 5.54 |
| CHEMBL4587873 | — | — | 1 | 5.40 |
| CHEMBL4556036 | — | — | 1 | 5.28 |
| CHEMBL4563305 | — | — | 1 | 5.28 |
| CHEMBL4559822 | — | — | 1 | 5.21 |
| CHEMBL4464827 | — | — | 1 | 5.05 |
| CHEMBL4441472 | — | — | 1 | 5.01 |
| CHEMBL4469283 | — | — | 1 | 4.82 |
| CHEMBL4576078 | — | — | 1 | 4.77 |
| CHEMBL4543409 | — | — | 1 | 4.75 |
| CHEMBL4447796 | — | — | 1 | 4.75 |
| CHEMBL4589384 | — | — | 1 | 4.75 |
| CHEMBL4529723 | — | — | 1 | 4.54 |
| CHEMBL4545625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475680 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4466601 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4552396 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4524329 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4465025 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4558399 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4464652 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4546986 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4460784 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4462995 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4549484 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4536649 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4584721 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4469817 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4566670 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4441859 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4463329 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4587873 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4556036 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4563305 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4559822 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4464827 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4441472 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4469283 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4576078 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4543409 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4447796 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4589384 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4529723 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4545625 | — | IC50 | - | — | - | |
| CHEMBL4444678 | — | IC50 | - | — | - | |
| CHEMBL4438796 | — | IC50 | - | — | - | |
| CHEMBL4556838 | — | IC50 | - | — | - | |
| CHEMBL4572185 | — | IC50 | - | — | - |