Compound Detail
CHEMBL4545625
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Basic Information
| ChEMBL ID | CHEMBL4545625 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXCLMJIJBABXKB-ZDUSSCGKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
300.7
MW (Da)
0.69
ALogP
3
HBA
2
HBD
69.6
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 2 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues)... | 30939017 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30939017 | 10.1021/acs.jmedchem.9b00041 | Methionine aminopeptidase 2 | 1 |
| 30939017 | 10.1021/acs.jmedchem.9b00041 | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine