Assay Detail
ADMET
CHEMBL4397106
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Activation of non-specific gene expression in human J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as CMV driven gene expression incubated for 48 hr by FACSCalibur flow cytometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.38 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.40 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.28 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL4446565 | — | — | 1 | 5.70 |
| CHEMBL4460170 | — | — | 1 | 5.20 |
| CHEMBL4540359 | — | — | 1 | 4.89 |
| CHEMBL4445805 | — | — | 1 | 4.75 |
| CHEMBL4435131 | — | — | 1 | 4.72 |
| CHEMBL4549436 | — | — | 1 | 4.55 |
| CHEMBL4552693 | — | — | 1 | 4.54 |
| CHEMBL4583543 | — | — | 1 | - |
| CHEMBL4467303 | — | — | 1 | - |
| CHEMBL4465202 | — | — | 1 | - |
| CHEMBL2132936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL343448 | ROMIDEPSIN | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4446565 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4460170 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4540359 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4445805 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4435131 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4549436 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4552693 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4583543 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4467303 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL4465202 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL2132936 | — | EC50 | > | 40000.0 | nM | - |