Assay Detail
Binding
CHEMBL4397121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal GST-tagged human SET1B (1629 to 1923 amino acids) expressed in Escherichia coli using core histone as substrate in presence of WDR5 (22 to 334 amino acids),RbBP5 (1 to 538 amino acids),Ash2L (2 to 534 amino acids),DPY-30 (1 to 99 amino acids) by fluorescence method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase SETD1B (CHEMBL4105837) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.85 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465202 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465202 | — | IC50 | = | 14000.0 | nM | 4.85 |