Assay Detail
Binding
CHEMBL4397304
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Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 60 mins by fluorescence method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Lysate |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological Chaperones for the Treatment of α-Mannosidosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.10 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465842 | — | — | 1 | 6.36 |
| CHEMBL4462117 | — | — | 1 | 5.66 |
| CHEMBL4475419 | — | — | 1 | 4.76 |
| CHEMBL4457217 | — | — | 1 | 4.71 |
| CHEMBL4471561 | — | — | 1 | 4.57 |
| CHEMBL4518572 | — | — | 1 | 4.51 |
| CHEMBL4435118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465842 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4462117 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4475419 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4457217 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4471561 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL4518572 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL4435118 | — | IC50 | = | 116000.0 | nM | - |