Assay Detail
Functional
CHEMBL4397979
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Antiproliferative activity against human A375 cells assessed as decrease in cell viability after 72 hrs by CCK-8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.42 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564104 | — | — | 1 | 5.81 |
| CHEMBL4437852 | — | — | 1 | 5.81 |
| CHEMBL4450474 | — | — | 1 | 5.62 |
| CHEMBL4442482 | — | — | 1 | 5.54 |
| CHEMBL4446236 | — | — | 1 | 5.52 |
| CHEMBL4517821 | — | — | 1 | 5.44 |
| CHEMBL4470564 | — | — | 1 | 5.43 |
| CHEMBL4437865 | — | — | 1 | 5.43 |
| CHEMBL4546654 | — | — | 1 | 5.43 |
| CHEMBL4592901 | — | — | 1 | 5.41 |
| CHEMBL4460015 | — | — | 1 | 5.36 |
| CHEMBL4087968 | — | — | 1 | 5.32 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.02 |
| CHEMBL4529709 | — | — | 1 | 4.80 |
| CHEMBL4472558 | — | — | 1 | - |
| CHEMBL4435848 | — | — | 1 | - |
| CHEMBL4581375 | — | — | 1 | - |
| CHEMBL4474140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564104 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4437852 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4450474 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4442482 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL4446236 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4517821 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4470564 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4437865 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4546654 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4592901 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4460015 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4087968 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL4529709 | — | IC50 | = | 15740.0 | nM | 4.80 |
| CHEMBL4472558 | — | IC50 | - | — | - | |
| CHEMBL4435848 | — | IC50 | - | — | - | |
| CHEMBL4581375 | — | IC50 | - | — | - | |
| CHEMBL4474140 | — | IC50 | - | — | - |