Assay Detail
ADMET
CHEMBL4397985
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Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.45 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437852 | — | — | 1 | 5.73 |
| CHEMBL4087968 | — | — | 1 | 5.62 |
| CHEMBL4437865 | — | — | 1 | 5.48 |
| CHEMBL4450474 | — | — | 1 | 5.44 |
| CHEMBL4446236 | — | — | 1 | 5.39 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437852 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4087968 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4437865 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4450474 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4446236 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 9050.0 | nM | 5.04 |