Assay Detail

CHEMBL4398327

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Binding

Inhibition of dengue virus NS5 RNA dependent RNA polymerase

ChEMBL ↗

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Target

Nonstructural protein 5 (CHEMBL4295629) ↗

Open DB target context

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Primary target Nonstructural protein 5

CHEMBL4295629

Anchored from Assay target.

Protein identity Nonstructural protein 5

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Dengue virus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Nonstructural protein 5 (CHEMBL4295629) ↗

Type	SINGLE PROTEIN
Organism	Dengue virus

Publication

Recent update on anti-dengue drug discovery.

Dighe SN, Ekwudu O, Dua K, Chellappan DK, Katavic PL, Collet TA.
Eur J Med Chem (2019) 176 : 431 -455
PubMed 31128447 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.77	5.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL82242	QUERCITRIN	—	1	5.77
CHEMBL269277	BETULINIC ACID	1.0	1	5.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL82242	QUERCITRIN	IC50	=	1700.0	nM	5.77
CHEMBL269277	BETULINIC ACID	IC50	=	1700.0	nM	5.77