Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4398437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sulfatase (unknown origin)
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Steryl-sulfatase (CHEMBL3559)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Estrogen signaling: An emanating therapeutic target for breast cancer treatment.
Saha T, Makar S, Swetha R, Gutti G, Singh SK.
Eur J Med Chem (2019) 177 : 116 -143
PubMed 31129450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.94 8.60
Ki 3 4.50 4.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4465348 1 8.60
CHEMBL3622029 1 8.52
CHEMBL322322 1 7.70
CHEMBL1627429 1 7.62
CHEMBL3622063 1 7.58
CHEMBL518966 1 7.55
CHEMBL108483 1 7.41
CHEMBL4529949 1 7.25
CHEMBL361700 1 6.75
CHEMBL3622064 1 6.69
CHEMBL4520455 1 5.06
CHEMBL184540 1 5.03
CHEMBL1628004 1 4.55
CHEMBL33862 1 4.45
CHEMBL4576206 1 4.42
CHEMBL32172 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4465348 IC50 = 2.5 nM 8.60
CHEMBL3622029 IC50 = 3.0 nM 8.52
CHEMBL322322 IC50 = 20.0 nM 7.70
CHEMBL1627429 IC50 = 24.0 nM 7.62
CHEMBL3622063 IC50 = 26.0 nM 7.58
CHEMBL518966 IC50 = 28.0 nM 7.55
CHEMBL108483 IC50 = 39.0 nM 7.41
CHEMBL4529949 IC50 = 55.8 nM 7.25
CHEMBL361700 IC50 = 180.0 nM 6.75
CHEMBL3622064 IC50 = 205.0 nM 6.69
CHEMBL4520455 IC50 = 8700.0 nM 5.06
CHEMBL184540 IC50 = 9400.0 nM 5.03
CHEMBL1628004 Ki = 28000.0 nM 4.55
CHEMBL33862 Ki = 35900.0 nM 4.45
CHEMBL4576206 IC50 = 37800.0 nM 4.42
CHEMBL32172 Ki > 500000.0 nM -