Assay Detail
Binding
CHEMBL4398457
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Inhibition of Bcl-xL (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The chemical biology of apoptosis: Revisited after 17 years.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.64 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342187 | — | — | 1 | 8.96 |
| CHEMBL1269107 | — | — | 1 | 7.12 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.55 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.32 |
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.55 |
| CHEMBL408194 | OBATOCLAX | 3.0 | 1 | 5.33 |
| CHEMBL4085804 | — | — | 1 | - |
| CHEMBL3793424 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342187 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1269107 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL376408 | ABT 737 | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL551288 | APOGOSSYPOL | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL408194 | OBATOCLAX | Ki | = | 4690.0 | nM | 5.33 |
| CHEMBL4085804 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3793424 | — | Ki | < | 0.01 | nM | - |