Assay Detail
Functional
CHEMBL4398836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity human NCI-H1975 cells incubated for 72 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR<sup>L858R/T790M/C797S</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.52 |
| CHEMBL4443483 | — | — | 1 | 5.52 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4443483 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL3545311 | BRIGATINIB | IC50 | - | — | - |