Assay Detail
Binding
CHEMBL4399181
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Inhibition of FGFR1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 8.82 |
| CHEMBL4449189 | — | — | 1 | 6.89 |
| CHEMBL4573547 | — | — | 1 | 6.55 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4449189 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4573547 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 670.0 | nM | 6.17 |