Assay Detail
Binding
CHEMBL4399183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-kit (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.33 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.10 |
| CHEMBL4449189 | — | — | 1 | 6.60 |
| CHEMBL4573547 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4449189 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4573547 | — | IC50 | = | 5160.0 | nM | 5.29 |