Assay Detail
Functional
CHEMBL4399378
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Antibacterial activity against methicillin resistant Staphylococcus aureus USA300 JE2 incubated for 18 hrs by broth microdilution method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.26 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.48 |
| CHEMBL268789 | — | — | 1 | 5.75 |
| CHEMBL570590 | — | — | 1 | 5.57 |
| CHEMBL4470202 | — | — | 1 | 5.55 |
| CHEMBL4434652 | — | — | 1 | 5.46 |
| CHEMBL4528161 | — | — | 1 | 5.44 |
| CHEMBL4537661 | — | — | 1 | 5.43 |
| CHEMBL4540097 | — | — | 1 | 5.42 |
| CHEMBL4437628 | — | — | 1 | 5.41 |
| CHEMBL570823 | — | — | 1 | 5.40 |
| CHEMBL4543136 | — | — | 1 | 5.32 |
| CHEMBL583257 | — | — | 1 | 5.16 |
| CHEMBL585744 | — | — | 1 | 5.16 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.08 |
| CHEMBL4462055 | — | — | 1 | 5.01 |
| CHEMBL567828 | — | — | 1 | 4.57 |
| CHEMBL4435437 | — | — | 1 | 4.28 |
| CHEMBL4593973 | — | — | 1 | 4.11 |
| CHEMBL4467757 | — | — | 1 | - |
| CHEMBL4534552 | — | — | 1 | - |
| CHEMBL4567638 | — | — | 1 | - |
| CHEMBL4436570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL268789 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL570590 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4470202 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4434652 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4528161 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4537661 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4540097 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4437628 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL570823 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4543136 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL583257 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL585744 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL8 | CIPROFLOXACIN | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4462055 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL567828 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4435437 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL4593973 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4467757 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4534552 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4567638 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL4436570 | — | EC50 | > | 100000.0 | nM | - |