Assay Detail
Functional
CHEMBL4399388
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Antibacterial activity against methicillin resistant Staphylococcus aureus USA300 JE2 incubated for 17 hrs by growth rate method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.32 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4540097 | — | — | 1 | 5.55 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.28 |
| CHEMBL585744 | — | — | 1 | 5.23 |
| CHEMBL583257 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4540097 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL8 | CIPROFLOXACIN | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL585744 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL583257 | — | EC50 | = | 6200.0 | nM | 5.21 |