Assay Detail
Functional
CHEMBL4399466
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Cytotoxicity against human CEM/DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-DNR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.17 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 7.80 |
| CHEMBL4541489 | — | — | 1 | 7.12 |
| CHEMBL2322512 | — | — | 1 | 6.65 |
| CHEMBL576300 | — | — | 1 | 6.57 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.50 |
| CHEMBL4516037 | — | — | 1 | 5.82 |
| CHEMBL4439788 | — | — | 1 | 5.77 |
| CHEMBL1800908 | — | — | 1 | 5.72 |
| CHEMBL4573300 | — | — | 1 | 5.51 |
| CHEMBL4546822 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL4541489 | — | IC50 | = | 76.3 | nM | 7.12 |
| CHEMBL2322512 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL576300 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL4516037 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4439788 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL1800908 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4573300 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4546822 | — | IC50 | = | 54300.0 | nM | 4.26 |