Assay Detail
ADMET
CHEMBL4399474
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Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.49 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.54 |
| CHEMBL1800908 | — | — | 1 | 7.15 |
| CHEMBL330407 | — | — | 1 | 7.06 |
| CHEMBL4516037 | — | — | 1 | 6.86 |
| CHEMBL4541489 | — | — | 1 | 6.85 |
| CHEMBL2322512 | — | — | 1 | 6.54 |
| CHEMBL576300 | — | — | 1 | 6.51 |
| CHEMBL4439788 | — | — | 1 | 5.21 |
| CHEMBL4573300 | — | — | 1 | 4.72 |
| CHEMBL4546822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL1800908 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL330407 | — | IC50 | = | 87.3 | nM | 7.06 |
| CHEMBL4516037 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4541489 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL2322512 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL576300 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4439788 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4573300 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4546822 | — | IC50 | = | 117000.0 | nM | - |