Assay Detail
Binding
CHEMBL4399508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Noncompetitive inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for 30 mins followed by substrate addition and measured after 3 hrs by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (CHEMBL3112379) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254269 | MALABARICONE A | — | 1 | 6.00 |
| CHEMBL489354 | MALABARICONE B | — | 1 | 6.00 |
| CHEMBL524100 | MALABARICONE C | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254269 | MALABARICONE A | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL489354 | MALABARICONE B | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL524100 | MALABARICONE C | IC50 | = | 1000.0 | nM | 6.00 |