Assay Detail
Functional
CHEMBL4399600
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Inhibition of IL-2 secretion from human PBMC cells stimulated with anti-CD3/CD28 measured after 24 hrs by bead-based FLISA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.78 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569479 | — | — | 1 | 8.00 |
| CHEMBL4469412 | — | — | 1 | 7.70 |
| CHEMBL4528271 | — | — | 1 | 7.70 |
| CHEMBL4590477 | — | — | 1 | 7.22 |
| CHEMBL4589844 | — | — | 1 | 7.05 |
| CHEMBL4532737 | — | — | 1 | 7.00 |
| CHEMBL4457150 | — | — | 1 | 6.89 |
| CHEMBL4461370 | — | — | 1 | 6.77 |
| CHEMBL4454086 | — | — | 1 | 6.70 |
| CHEMBL4461649 | — | — | 1 | 6.68 |
| CHEMBL4567363 | — | — | 1 | 6.60 |
| CHEMBL4522851 | — | — | 1 | 6.58 |
| CHEMBL4566843 | — | — | 1 | 6.52 |
| CHEMBL4541215 | — | — | 1 | 6.48 |
| CHEMBL4584166 | — | — | 1 | 6.46 |
| CHEMBL4587816 | — | — | 1 | 6.35 |
| CHEMBL4435004 | — | — | 1 | 6.26 |
| CHEMBL4444700 | — | — | 1 | 6.24 |
| CHEMBL4447253 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569479 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4469412 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4528271 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4590477 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4589844 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4532737 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4457150 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4461370 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4454086 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4461649 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4567363 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4522851 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4566843 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4541215 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4584166 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4587816 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4435004 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4444700 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4447253 | — | IC50 | = | 2700.0 | nM | 5.57 |