Compound Detail
CHEMBL4522851
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4522851 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NRLBDRFDRQIPKZ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
294.4
MW (Da)
3.56
ALogP
3
HBA
2
HBD
67.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.58
Ki 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C theta type CHEMBL3920 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C theta type | Ki | = | 5.0 | nM | 8.3 | Inhibition of human recombinant full length His tagged PKC theta expressed in ba... | 31417666 |
| PBMC | IC50 | = | 260.0 | nM | 6.58 | Inhibition of IL-2 secretion from human PBMC cells stimulated with anti-CD3/CD28... | 31417666 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31417666 | 10.1021/acsmedchemlett.9b00134 | Protein kinase C theta type | 1 |
| 31417666 | 10.1021/acsmedchemlett.9b00134 | Unchecked | 1 |
| 31417666 | 10.1021/acsmedchemlett.9b00134 | PBMC | 1 |
Data from ChEMBL 36 via Core Engine