Assay Detail
Binding
CHEMBL4399998
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Inhibition of recombinant full length human TrkA transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.18 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4555143 | — | — | 1 | 7.50 |
| CHEMBL4447685 | — | — | 1 | 7.06 |
| CHEMBL4475899 | — | — | 1 | 6.11 |
| CHEMBL4525857 | — | — | 1 | 5.58 |
| CHEMBL4574596 | — | — | 1 | 5.39 |
| CHEMBL4472006 | — | — | 1 | 5.30 |
| CHEMBL1710419 | — | — | 1 | 5.18 |
| CHEMBL4535656 | — | — | 1 | 5.00 |
| CHEMBL4579301 | — | — | 1 | 4.70 |
| CHEMBL4573099 | — | — | 1 | 4.70 |
| CHEMBL4471969 | — | — | 1 | 4.70 |
| CHEMBL1707321 | — | — | 1 | 4.70 |
| CHEMBL4440941 | — | — | 1 | 4.70 |
| CHEMBL4473447 | — | — | 1 | 4.70 |
| CHEMBL4453766 | — | — | 1 | 4.70 |
| CHEMBL4444267 | — | — | 1 | 4.70 |
| CHEMBL4454926 | — | — | 1 | 4.70 |
| CHEMBL4534509 | — | — | 1 | 4.70 |
| CHEMBL4476611 | — | — | 1 | 4.70 |
| CHEMBL4469499 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4555143 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL4447685 | — | IC50 | = | 86.5 | nM | 7.06 |
| CHEMBL4475899 | — | IC50 | = | 773.5 | nM | 6.11 |
| CHEMBL4525857 | — | IC50 | = | 2637.4 | nM | 5.58 |
| CHEMBL4574596 | — | IC50 | = | 4071.2 | nM | 5.39 |
| CHEMBL4472006 | — | IC50 | = | 5043.0 | nM | 5.30 |
| CHEMBL1710419 | — | IC50 | = | 6616.8 | nM | 5.18 |
| CHEMBL4535656 | — | IC50 | = | 10050.9 | nM | 5.00 |
| CHEMBL4579301 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4573099 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4471969 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1707321 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4440941 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4473447 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4453766 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4444267 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4454926 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4534509 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4476611 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4469499 | — | IC50 | = | 20000.0 | nM | 4.70 |