Assay Detail
Binding
CHEMBL4400097
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Inhibition of activated human coagulation factor 11 using pyroGlu-Pro-Arg-pNA as substrate incubated for 10 to 120 mins by spectrofluorometric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.17 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071545 | — | — | 1 | 9.80 |
| CHEMBL4576507 | — | — | 1 | 9.57 |
| CHEMBL4467360 | — | — | 1 | 9.02 |
| CHEMBL4452300 | — | — | 1 | 8.74 |
| CHEMBL4550408 | — | — | 1 | 8.74 |
| CHEMBL4475559 | — | — | 1 | 8.68 |
| CHEMBL4460266 | — | — | 1 | 8.66 |
| CHEMBL4465144 | — | — | 1 | 8.36 |
| CHEMBL4551053 | — | — | 1 | 8.33 |
| CHEMBL4463167 | — | — | 1 | 8.32 |
| CHEMBL4438562 | — | — | 1 | 8.28 |
| CHEMBL4515523 | — | — | 1 | 7.77 |
| CHEMBL4552540 | — | — | 1 | 7.00 |
| CHEMBL4514410 | — | — | 1 | 6.70 |
| CHEMBL4558196 | — | — | 1 | 6.48 |
| CHEMBL4454856 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071545 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4576507 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL4467360 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL4452300 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4550408 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4475559 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4460266 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4465144 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL4551053 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4463167 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4438562 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL4515523 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4552540 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL4514410 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL4558196 | — | Ki | = | 333.0 | nM | 6.48 |
| CHEMBL4454856 | — | Ki | = | 560.0 | nM | 6.25 |