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Assay Detail

CHEMBL4400278

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Functional
Antiviral activity against Zika virus infected in human A549 cells assessed as reduction in viral titer incubated for 48 hrs by plaque assay
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Zika virus
Confidence 1 — Organism
Curated By Autocuration

Target

Zika virus (CHEMBL4296612) ↗
Type ORGANISM
Organism Zika virus

Publication

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection.
Khachatoorian R, Micewicz ED, Micewicz A, French SW, Ruchala P.
Bioorg Med Chem Lett (2019) 29 : 126626 -126626
PubMed 31477351 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 8.11 10.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4475511 — — 1 10.07
CHEMBL4557508 — — 1 10.01
CHEMBL4555491 — — 1 10.01
CHEMBL4469100 — — 1 10.00
CHEMBL4591065 — — 1 9.96
CHEMBL4465951 — — 1 9.95
CHEMBL4460915 — — 1 9.84
CHEMBL4455297 — — 1 9.83
CHEMBL4435841 — — 1 9.83
CHEMBL4514485 — — 1 9.81
CHEMBL4529440 — — 1 9.75
CHEMBL4207559 — — 1 9.72
CHEMBL4536703 — — 1 9.72
CHEMBL4471319 — — 1 9.48
CHEMBL4454744 — — 1 9.38
CHEMBL4519481 — — 1 9.37
CHEMBL4542274 — — 1 9.18
CHEMBL4450441 — — 1 9.09
CHEMBL4212750 — — 1 9.02
CHEMBL4471227 — — 1 9.01
CHEMBL4483444 — — 1 8.85
CHEMBL4436883 — — 1 8.31
CHEMBL4525531 — — 1 7.33
CHEMBL4466830 — — 1 7.24
CHEMBL4575570 — — 1 6.63
CHEMBL4440325 — — 1 6.31
CHEMBL4573163 — — 1 6.15
CHEMBL4464172 — — 1 6.00
CHEMBL4591242 — — 1 5.92
CHEMBL4470306 — — 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4475511 — IC50 = 0.0851 nM 10.07
CHEMBL4557508 — IC50 = 0.0977 nM 10.01
CHEMBL4555491 — IC50 = 0.0977 nM 10.01
CHEMBL4469100 — IC50 = 0.1002 nM 10.00
CHEMBL4591065 — IC50 = 0.1109 nM 9.96
CHEMBL4465951 — IC50 = 0.1135 nM 9.95
CHEMBL4460915 — IC50 = 0.1435 nM 9.84
CHEMBL4455297 — IC50 = 0.1491 nM 9.83
CHEMBL4435841 — IC50 = 0.1466 nM 9.83
CHEMBL4514485 — IC50 = 0.1563 nM 9.81
CHEMBL4529440 — IC50 = 0.1791 nM 9.75
CHEMBL4207559 — IC50 = 0.191 nM 9.72
CHEMBL4536703 — IC50 = 0.191 nM 9.72
CHEMBL4471319 — IC50 = 0.3289 nM 9.48
CHEMBL4454744 — IC50 = 0.414 nM 9.38
CHEMBL4519481 — IC50 = 0.4227 nM 9.37
CHEMBL4542274 — IC50 = 0.6653 nM 9.18
CHEMBL4450441 — IC50 = 0.8091 nM 9.09
CHEMBL4212750 — IC50 = 0.9616 nM 9.02
CHEMBL4471227 — IC50 = 0.9822 nM 9.01
CHEMBL4483444 — IC50 = 1.4 nM 8.85
CHEMBL4436883 — IC50 = 4.9 nM 8.31
CHEMBL4525531 — IC50 = 46.6 nM 7.33
CHEMBL4466830 — IC50 = 57.4 nM 7.24
CHEMBL4575570 — IC50 = 233.3 nM 6.63
CHEMBL4440325 — IC50 = 493.2 nM 6.31
CHEMBL4573163 — IC50 = 706.3 nM 6.15
CHEMBL4464172 — IC50 = 1000.0 nM 6.00
CHEMBL4591242 — IC50 = 1200.0 nM 5.92
CHEMBL4470306 — IC50 = 1300.0 nM 5.89
CHEMBL4472946 — IC50 = 2100.0 nM 5.68
CHEMBL4466194 — IC50 = 2600.0 nM 5.58
CHEMBL4450589 — IC50 = 2600.0 nM 5.58
CHEMBL4571581 — IC50 = 2700.0 nM 5.57
CHEMBL4526453 — IC50 = 2900.0 nM 5.54
CHEMBL4461661 — IC50 = 4100.0 nM 5.39
CHEMBL4457497 — IC50 = 9100.0 nM 5.04
CHEMBL4448764 — IC50 = 3300000.0 nM -
CHEMBL4464693 — IC50 = 5100000.0 nM -