Assay Detail
Binding
CHEMBL4400641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Placenta |
| Subcellular | Microsomal |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.54 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457145 | — | — | 1 | 9.70 |
| CHEMBL4529443 | — | — | 1 | 9.70 |
| CHEMBL4546082 | — | — | 1 | 9.40 |
| CHEMBL4464314 | — | — | 1 | 9.40 |
| CHEMBL4574253 | — | — | 1 | 9.05 |
| CHEMBL4441152 | — | — | 1 | 8.92 |
| CHEMBL4552641 | — | — | 1 | 8.85 |
| CHEMBL4450585 | — | — | 1 | 8.74 |
| CHEMBL4285743 | — | — | 1 | 8.70 |
| CHEMBL4582194 | — | — | 1 | 8.25 |
| CHEMBL4459887 | — | — | 1 | 8.17 |
| CHEMBL4461477 | — | — | 1 | 8.16 |
| CHEMBL4538007 | — | — | 1 | 8.07 |
| CHEMBL4519897 | — | — | 1 | 7.86 |
| CHEMBL3629438 | — | — | 1 | 6.96 |
| CHEMBL4459492 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457145 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4529443 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4546082 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4464314 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4574253 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4441152 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4552641 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4450585 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4285743 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4582194 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4459887 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4461477 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4538007 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4519897 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL3629438 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4459492 | — | IC50 | = | 231.0 | nM | 6.64 |