Assay Detail
Binding
CHEMBL4401223
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Inhibition of estrogen receptor-alpha (unknown origin) by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.00 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 8.82 |
| CHEMBL4590512 | — | — | 1 | 8.75 |
| CHEMBL4435453 | — | — | 1 | 8.62 |
| CHEMBL4539135 | — | — | 1 | 8.48 |
| CHEMBL4468912 | — | — | 1 | 8.33 |
| CHEMBL4444460 | — | — | 1 | 8.12 |
| CHEMBL4555331 | — | — | 1 | 8.09 |
| CHEMBL4571261 | — | — | 1 | 7.64 |
| CHEMBL4553545 | — | — | 1 | 7.35 |
| CHEMBL4570601 | — | — | 1 | 7.16 |
| CHEMBL4516755 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83 | TAMOXIFEN | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4590512 | — | IC50 | = | 1.76 | nM | 8.75 |
| CHEMBL4435453 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4539135 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL4468912 | — | IC50 | = | 4.71 | nM | 8.33 |
| CHEMBL4444460 | — | IC50 | = | 7.53 | nM | 8.12 |
| CHEMBL4555331 | — | IC50 | = | 8.15 | nM | 8.09 |
| CHEMBL4571261 | — | IC50 | = | 22.67 | nM | 7.64 |
| CHEMBL4553545 | — | IC50 | = | 44.43 | nM | 7.35 |
| CHEMBL4570601 | — | IC50 | = | 69.46 | nM | 7.16 |
| CHEMBL4516755 | — | IC50 | = | 204.75 | nM | 6.69 |