Assay Detail
Functional
CHEMBL4401552
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Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by presto-blue assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.73 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447855 | — | — | 1 | 6.64 |
| CHEMBL4514888 | — | — | 1 | 6.16 |
| CHEMBL4520682 | — | — | 1 | 6.14 |
| CHEMBL4472721 | — | — | 1 | 6.12 |
| CHEMBL4468286 | — | — | 1 | 6.04 |
| CHEMBL4517351 | — | — | 1 | 5.98 |
| CHEMBL4449309 | — | — | 1 | 5.93 |
| CHEMBL4459580 | — | — | 1 | 5.89 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.85 |
| CHEMBL4524717 | — | — | 1 | 5.85 |
| CHEMBL4438662 | — | — | 1 | 5.81 |
| CHEMBL4436721 | — | — | 1 | 5.72 |
| CHEMBL4443002 | — | — | 1 | 5.54 |
| CHEMBL4457799 | — | — | 1 | 5.52 |
| CHEMBL4532445 | — | — | 1 | 5.48 |
| CHEMBL4442188 | — | — | 1 | 5.46 |
| CHEMBL4514483 | — | — | 1 | 5.44 |
| CHEMBL4467023 | — | — | 1 | 5.43 |
| CHEMBL4447566 | — | — | 1 | 5.39 |
| CHEMBL4469473 | — | — | 1 | 5.35 |
| CHEMBL4446922 | — | — | 1 | 5.21 |
| CHEMBL4436996 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447855 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4514888 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4520682 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4472721 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4468286 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4517351 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4449309 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4459580 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4524717 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4438662 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4436721 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4443002 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4457799 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL4532445 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL4442188 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4514483 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4467023 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4447566 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4469473 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL4446922 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL4436996 | — | IC50 | = | 6630.0 | nM | 5.18 |