Assay Detail
Functional
CHEMBL4401555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by presto-blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.60 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447855 | — | — | 1 | 6.40 |
| CHEMBL4472721 | — | — | 1 | 5.78 |
| CHEMBL4514888 | — | — | 1 | 5.77 |
| CHEMBL4520682 | — | — | 1 | 5.61 |
| CHEMBL4468286 | — | — | 1 | 5.40 |
| CHEMBL4436996 | — | — | 1 | 5.28 |
| CHEMBL4457799 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447855 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4472721 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4514888 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4520682 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4468286 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4436996 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4457799 | — | IC50 | = | 11530.0 | nM | 4.94 |