Assay Detail
Functional
CHEMBL4401565
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Cytotoxicity against human EAhy926 cells assessed as reduction in cell viability after 72 hrs by presto-blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.20 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447855 | — | — | 1 | 5.85 |
| CHEMBL4457799 | — | — | 1 | 5.05 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447855 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4457799 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL101253 | VATALANIB | IC50 | = | 19980.0 | nM | 4.70 |