Assay Detail
Binding
CHEMBL4401913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.77 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345298 | — | — | 1 | 9.08 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.92 |
| CHEMBL4572914 | — | — | 1 | 8.85 |
| CHEMBL4588745 | — | — | 1 | 8.82 |
| CHEMBL4459692 | — | — | 1 | 8.72 |
| CHEMBL4449668 | — | — | 1 | 8.66 |
| CHEMBL4439399 | — | — | 1 | 8.60 |
| CHEMBL4438880 | — | — | 1 | 8.47 |
| CHEMBL4531897 | — | — | 1 | 7.96 |
| CHEMBL4562084 | — | — | 1 | 7.96 |
| CHEMBL198997 | — | — | 1 | 7.92 |
| CHEMBL4469143 | — | — | 1 | 7.85 |
| CHEMBL4517145 | — | — | 1 | 7.55 |
| CHEMBL4448702 | — | — | 1 | 7.33 |
| CHEMBL4439947 | — | — | 1 | 7.20 |
| CHEMBL4442948 | — | — | 1 | 6.96 |
| CHEMBL4539676 | — | — | 1 | 6.92 |
| CHEMBL4590840 | — | — | 1 | 6.37 |
| CHEMBL4215742 | — | — | 1 | 5.91 |
| CHEMBL4437942 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345298 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL38 | TRETINOIN | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4572914 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4588745 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4459692 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4449668 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4439399 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4438880 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4531897 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4562084 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL198997 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4469143 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4517145 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4448702 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4439947 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4442948 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4539676 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4590840 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4215742 | — | EC50 | = | 1227.0 | nM | 5.91 |
| CHEMBL4437942 | — | EC50 | = | 4200.0 | nM | 5.38 |