Assay Detail
Binding
CHEMBL4401964
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Inhibition of human factor Xa using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate preincubated for 15 mins followed by substrate addition by UV absorption analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Semisynthesis of epoxy-pimarane diterpenoids from kirenol and their FXa inhibition activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.57 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269025 | EDOXABAN | 4.0 | 1 | 8.47 |
| CHEMBL4526357 | — | — | 1 | 6.66 |
| CHEMBL4561623 | — | — | 1 | 6.02 |
| CHEMBL4474248 | — | — | 1 | 5.77 |
| CHEMBL1089731 | KIRENOL | — | 1 | 5.60 |
| CHEMBL4555342 | — | — | 1 | 5.33 |
| CHEMBL4452613 | — | — | 1 | 5.21 |
| CHEMBL4577469 | — | — | 1 | 5.14 |
| CHEMBL4581081 | — | — | 1 | 5.13 |
| CHEMBL4455162 | — | — | 1 | 5.10 |
| CHEMBL4560959 | — | — | 1 | 4.75 |
| CHEMBL4464490 | — | — | 1 | 4.73 |
| CHEMBL4468511 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269025 | EDOXABAN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4526357 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4561623 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4474248 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1089731 | KIRENOL | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4555342 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4452613 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4577469 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4581081 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4455162 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4560959 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4464490 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL4468511 | — | IC50 | = | 27900.0 | nM | 4.55 |