Assay Detail
Binding
CHEMBL4402140
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Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.07 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568027 | — | — | 1 | 6.91 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4448979 | — | — | 1 | 6.42 |
| CHEMBL4552193 | — | — | 1 | 6.38 |
| CHEMBL4587801 | — | — | 1 | 6.36 |
| CHEMBL4574353 | — | — | 1 | 6.34 |
| CHEMBL4539483 | — | — | 1 | 6.28 |
| CHEMBL4452439 | — | — | 1 | 6.23 |
| CHEMBL4552490 | — | — | 1 | 6.17 |
| CHEMBL4444999 | — | — | 1 | 6.14 |
| CHEMBL4451848 | — | — | 1 | 6.14 |
| CHEMBL4462536 | — | — | 1 | 6.13 |
| CHEMBL4456216 | — | — | 1 | 6.08 |
| CHEMBL4557185 | — | — | 1 | 6.08 |
| CHEMBL4461238 | — | — | 1 | 6.06 |
| CHEMBL4467853 | — | — | 1 | 6.03 |
| CHEMBL4537582 | — | — | 1 | 5.91 |
| CHEMBL4458581 | — | — | 1 | 5.88 |
| CHEMBL4556985 | — | — | 1 | 5.49 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 5.29 |
| CHEMBL4447240 | — | — | 1 | 5.28 |
| CHEMBL4547531 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568027 | — | Ki | = | 122.1 | nM | 6.91 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4448979 | — | Ki | = | 381.6 | nM | 6.42 |
| CHEMBL4552193 | — | Ki | = | 415.4 | nM | 6.38 |
| CHEMBL4587801 | — | Ki | = | 441.7 | nM | 6.36 |
| CHEMBL4574353 | — | Ki | = | 458.7 | nM | 6.34 |
| CHEMBL4539483 | — | Ki | = | 522.2 | nM | 6.28 |
| CHEMBL4452439 | — | Ki | = | 591.3 | nM | 6.23 |
| CHEMBL4552490 | — | Ki | = | 681.1 | nM | 6.17 |
| CHEMBL4444999 | — | Ki | = | 722.9 | nM | 6.14 |
| CHEMBL4451848 | — | Ki | = | 724.3 | nM | 6.14 |
| CHEMBL4462536 | — | Ki | = | 736.8 | nM | 6.13 |
| CHEMBL4456216 | — | Ki | = | 829.6 | nM | 6.08 |
| CHEMBL4557185 | — | Ki | = | 840.9 | nM | 6.08 |
| CHEMBL4461238 | — | Ki | = | 864.2 | nM | 6.06 |
| CHEMBL4467853 | — | Ki | = | 935.8 | nM | 6.03 |
| CHEMBL4537582 | — | Ki | = | 1225.3 | nM | 5.91 |
| CHEMBL4458581 | — | Ki | = | 1317.4 | nM | 5.88 |
| CHEMBL4556985 | — | Ki | = | 3265.4 | nM | 5.49 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 5080.0 | nM | 5.29 |
| CHEMBL4447240 | — | Ki | = | 5312.5 | nM | 5.28 |
| CHEMBL4547531 | — | Ki | = | 5886.8 | nM | 5.23 |